Isabelle Arnulf

Saccadic network dysfunction underlies eye-movement variability in early Parkinson's disease

This study identifies increased intra-individual saccadic variability and altered functional connectivity in early Parkinson's disease, showing their potential as biomarkers for early diagnosis.

How sleeping minds decide: state-specific reconfigurations of lexical decision-making

This study uses computational modeling to show how lexical decision-making adapts across different sleep states, revealing state-specific changes in cognitive processing strategies.

Post-traumatic stress disorder and REM-sleep behavior disorder: exploring genetic associations and causal links

The paper investigates genetic and causal links between post-traumatic stress disorder and rapid-eye-movement sleep behavior disorder using polygenic risk scores, genetic correlation, and Mendelian randomization analyses.

Live access to the emotional dynamics of REM sleep dreams in lucid dreamers with narcolepsy

This study investigates the emotional dynamics of REM sleep dreams in lucid dreamers with narcolepsy by collecting real-time emotional valence reports during naps.

EEG Signature of Idiopathic Hypersomnia: Insights from Sleep Microarchitecture and Hypnodensity Metrics

The paper identifies EEG features distinguishing idiopathic hypersomnia from controls using sleep microarchitecture and hypnodensity metrics.

Lack of Epistatic Interaction of SNCA with APOE in Synucleinopathies

The paper investigates genetic interactions between SNCA and APOE in synucleinopathies using GWAS data and finds no significant epistatic interactions after multiple testing correction.

Longitudinal neuromelanin changes in prodromal and early Parkinson's disease in humans and rat model

The paper uses NM-sensitive MRI to study neuromelanin accumulation and neurodegeneration in Parkinson's disease models, finding a biphasic signal change linked to a pathogenic threshold.

The role of dopaminergic, cholinergic and noradrenergic networks in hyposmia in Parkinson's disease

This study investigates network alterations in olfactory dysfunction in Parkinson's disease and iRBD patients using multimodal MRI, finding correlations between olfactory function and specific brain regions and networks.

NPC1 variants are not associated with Parkinson's disease, REM-sleep behaviour disorder or Dementia with Lewy bodies in European cohorts.

This study examines the association of NPC1 variants with Parkinson's disease, REM-sleep behavior disorder, and dementia with Lewy bodies in European cohorts and finds no significant associations.

Memory loss at sleep onset

The paper shows that N1 sleep leads to more memory forgetting compared to N2 sleep, with alpha/theta power ratio linked to forgetting rates.

Behavioral and brain responses to verbal stimuli reveal transient periods of cognitive integration of external world in all sleep stages

The paper investigates behavioral responses to verbal stimuli in sleep stages, finding reactivity in all stages except slow-wave sleep in healthy volunteers.

Genome-wide association study of REM sleep behavior disorder identifies novel loci with distinct polygenic and brain expression effects

This study identifies five RBD risk loci through genome-wide association and finds differential expression of SNCA-AS1 and SCARB2 in brain regions.

Kleine Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci.

This study identifies a genetic association between Kleine-Levin Syndrome and variants in the TRANK1 gene, with increased risk linked to birth difficulties.

GBA variants in REM sleep behavior disorder: a multicenter study

This study investigates the association between GBA variants and risk for isolated REM sleep behavior disorder (iRBD) and conversion to neurodegeneration, finding higher prevalence and increased conversion rates in carriers.

Fine-mapping of SNCA in REM sleep behavior disorder and overt synucleinopathies

This study identifies SNCA risk variants specific to RBD and overt synucleinopathies, finding distinct associations and opposite effects at the 3' end of SNCA.

Narcolepsy risk loci are enriched in immune cells and suggest autoimmune modulation of the T cell receptor repertoire

This study identifies genetic risk loci for narcolepsy, showing enrichment in immune cells and suggesting autoimmune modulation via T cell receptor chains and influenza-A infection.