Ziv Gan‐Or

This study characterizes the genetic and clinical features of hereditary spastic paraplegia (HSP) in a Canadian cohort, identifying common genetic causes and phenotypic variability.

The paper examines how genetic variants in GALC affect the ratio of glucocerebrosidase to galactosylceramidase activity and its association with Parkinson's disease risk.

GBAviewer maps GBA1 variants onto GCase structures to aid in understanding their structural impact on Parkinson's disease.

This study examines the association between PGK1 variants and Parkinson's disease but finds no evidence of such a link in large cohorts.

The paper investigates the genetic role of SLC25A46 in Parkinson's disease, REM sleep behavior disorder, and Dementia with Lewy Bodies, finding no significant associations.

HippoGenes creates transcriptomic maps of the human hippocampus using spatial statistical models and the Allen Human Brain Atlas, enabling subregional gene expression analysis and disease-related molecular decoding.

This study investigates the genetic role of SLC7A11 in Parkinson's Disease using whole-genome sequencing data and finds no association between SLC7A11 variants and PD risk or GCase activity.

The paper investigates the role of the BMP pathway in Parkinson's disease using genetic and pharmacological approaches, finding it contributes to polygenic risk and has therapeutic potential.

This study finds the GBA1 p.E427K variant increases risk for synucleinopathies through a meta-analysis of case-control studies.

This study identifies digenic inheritance of SPG7 and AFG3L2 mutations as a cause of motor neuron and cerebellar disorders in 17 patients.

The paper integrates machine learning and rare variant burden analysis to identify novel candidate genes for Parkinson's disease.

This study investigates ANO6's role in Parkinson's disease by analyzing common and rare variants across large datasets, finding no strong genetic association.

This study uses Mendelian Randomization to test if TNF pathway genes are genetically linked to Parkinson's disease or RBD, finding no evidence of such a link.

The paper investigates whether CPT1C loss-of-function variants cause hereditary spastic paraplegia (HSP) by analyzing genomic data from multiple cohorts and finds no causal association.

The paper assesses the contribution of unknown GBA1 variants to Parkinson's disease risk and their relevance for clinical trial stratification.

This study investigates how LRRK2 kinase activity affects GCase activity in microglia under inflammatory conditions, finding that LRRK2 variants influence GCase response to interferon gamma.

This study identifies genetic variants associated with REM sleep behavior disorder in Parkinson's disease and explores genetic correlations with neuropsychiatric traits.

The paper investigates genetic and causal links between post-traumatic stress disorder and rapid-eye-movement sleep behavior disorder using polygenic risk scores, genetic correlation, and Mendelian randomization analyses.

The paper examines associations between epilepsy-related polygenic risk scores and brain morphology in children, finding PRS-related cortical thinning linked to structural patterns in TLE-HS patients.

This study uses Mendelian randomization to find coffee consumption is causally linked to later age-at-onset of Parkinson's disease but not to disease risk or progression.

The paper identifies three latent genetic factors of impulsivity and risk-taking traits and links them to distinct brain structures and developmental patterns in children.

This study identifies genetic variants associated with glucocerebrosidase activity using GWAS in two cohorts, finding GBA1 variants and a novel association in the GAA locus.

This study investigates the association between G6PD variants and Parkinson's disease across six cohorts and finds no significant links for common or rare variants.

The paper investigates the role of ATP10D and GlcCer in Parkinson's disease, finding ATP10D regulates plasma GlcCer levels but is not involved in PD pathogenesis.

The paper investigates genetic interactions between SNCA and APOE in synucleinopathies using GWAS data and finds no significant epistatic interactions after multiple testing correction.

This study investigates the role of cathepsin B in Parkinson's disease by analyzing genetic variants and manipulating catB function in cell models to assess its impact on lysosomal activity and alpha-synuclein clearance.

This study investigates the association between rare SYNJ1 variants and Parkinson's disease, finding an association with both sporadic and early-onset cases.

This study investigates the genetic role of the NLRP3-inflammasome in Parkinson's disease using polygenic risk scores and Mendelian randomization, finding no significant associations.

The paper identifies rare SMPD1 variants in Asian populations that increase Parkinson's disease risk through exome sequencing and functional assays.

The paper uses machine learning to identify candidate genes, variants, and pathways potentially linked to Parkinson's disease from GWAS loci and genomic data.