Pengyuan Yang

The paper presents an ultradeep N-glycoproteome atlas of mouse tissues, revealing spatiotemporal patterns of glycosylation in brain aging and neurodegenerative diseases.

pGlycoQuant is a tool for quantitative glycopeptide analysis that reduces missing values using a deep residual network, enabling site-specific glycosylation studies in hepatocellular carcinoma.

GproDIA improves glycoproteomics by enabling accurate glycopeptide identification and quantification using DIA data with comprehensive statistical control.

OGP provides a comprehensive repository of O-glycoproteins and a prediction tool to facilitate O-glycosylation studies.

pGlyco3 is a glycan-first search engine for analyzing glycopeptides and modified saccharide units, offering faster performance without sacrificing accuracy.

This study uses multilayered N-glycoproteomics to show impaired N-glycosylation in Alzheimer's disease mouse models, affecting protein function and neuronal health.