Siva Karthik Varanasi

This study identifies a mechanism by which macrophage-derived IL-27 sustains autoreactive CD8+ T cells in autoimmune hepatitis through a local progenitor-to-effector pipeline.

This study shows that HIRA-mediated H3.3 deposition maintains hepatocyte identity during aging, and its loss leads to metabolic dysfunction and fibrosis, which can be partially reversed by tissue regeneration.

This study shows that aged livers have heightened interferon signaling that suppresses cancer but also has harmful effects, leading to a 'precarious balance' in tumor development.