Macrophage-derived IL-27 sustains autoreactive CD8+ cytotoxic T cells in autoimmune hepatitis
Kaiyuan Hao, Sofia Grace Baptista, Aurora Beaumond, Daniel Milo Schafer, Kevin MingJie Gao, Prasanthi Lalitha Kaja, Kristy Chiang, Kerstin Nündel, Sushmitha Vijaya Kumar, Marc Samuel Sherman, Ann Marshak‐Rothstein, Siva Karthik Varanasi
This study identifies a mechanism by which macrophage-derived IL-27 sustains autoreactive CD8+ T cells in autoimmune hepatitis through a local progenitor-to-effector pipeline.
bioRxiv · Sep 28, 2026 · PreprintImmunology