Ronald G. Gregg

This study shows that gene therapy targeting rod photoreceptors can restore synaptic structure, retinal function, and visual acuity in a mouse model of retinal dystrophy.

This study investigates the role of LRIT3 domains in synaptic assembly and retinal function, showing that the LRR and IG domains are critical for TRPM1 localization and signalplex function in retinal bipolar cells.

This study demonstrates that RHO1-2 meganuclease gene editing can arrest rod degeneration and restore retinal function in a pig model of P23H rhodopsin-induced retinitis pigmentosa.

This study demonstrates that gene augmentation therapy using rAAV-mediated LRIT3 expression in mature mice with cCSNB improves retinal function and visual acuity.

The paper identifies LRFN2 as a protein involved in cone photoreceptor synapse formation and function, showing its interaction with TRPM1 and its role in synaptic transmission.

This study shows that LRIT3 expression in cone photoreceptors rescues signalplex assembly and function in Lrit3-/- mice, restoring visual function through trans-synaptic effects.

The paper identifies glycinergic narrow field amacrine cells as a dominant inhibitory source for retinal ON starburst amacrine cells, revealing their role in modulating direction selectivity through ultra-slow glycine receptors.

This study shows LRIT3 is essential for nyctalopin and TRPM1 expression, affecting both ON and OFF pathway signaling in retinal bipolar cells.