Kazuki Takahashi

This study develops a 3D in vitro system to visualize tumor intravasation of CTC clusters and identifies TGF-β and activin signaling as essential for this process.

This study shows that CTCF-mediated 3D chromatin structure pre-establishes gene expression programs required for spermatogenesis by forming meiosis-specific super-enhancers and regulating chromatin loops.

This study identifies endogenous retroviruses as drivers of species-specific germline transcriptomes in mammals, particularly through their role in gene activation and enhancer function in spermatogenesis.

The paper shows that super-enhancer switching drives bursts in germline gene expression during the mitosis-to-meiosis transition in testis.