Xavier Jeunemaı̂tre

This study evaluates therapeutic strategies in a mouse model of vascular Ehlers-Danlos syndrome, finding that losartan reduces aortic rupture while angiotensin II increases mortality.

The paper performs a genome-wide association meta-analysis of mitral valve prolapse, identifying new risk loci and genes involved in cardiac development and aging.

The paper identifies rare loss-of-function mutations in PTGIR in FMD and SCAD patients, showing impaired prostacyclin receptor function and suggesting a role for prostacyclin signaling in these diseases.