Adrien B. Georges

This paper identifies rs13128814 as the causal variant at the ZNF827 locus linked to SCAD, CAD, and cardiovascular traits, showing it regulates ZNF827 expression via NF1 transcription factor binding.

The paper identifies genetic variants associated with spontaneous coronary artery dissection using multi-trait GWAS and gene-based analysis, revealing new loci and biological pathways.

This study identifies two genome-wide significant loci associated with hypermobile Ehlers-Danlos syndrome, implicating neuroimmune and pain signaling pathways and highlighting genetic correlations with multiple comorbid conditions.

This study identifies rs11172113 as the causal variant in LRP1 for vascular diseases and shows SNAIL represses LRP1 expression, leading to extracellular matrix remodeling through TGF-β signaling.

This study identifies 17 genetic risk loci for spontaneous coronary artery dissection (SCAD), including 12 new ones, and highlights genes related to artery integrity and coagulation.

The paper identifies rare loss-of-function mutations in PTGIR in FMD and SCAD patients, showing impaired prostacyclin receptor function and suggesting a role for prostacyclin signaling in these diseases.

The paper characterizes open chromatin profiles in human mitral valves to identify functional variants and target genes at MVP risk loci.