Talia DeFrancesco Oranburg

The paper identifies a silencer element lost in ADLD patients that specifically targets oligodendrocyte overexpression of LMNB1, linking it to disease pathogenesis.

This paper reassesses Hardy-Weinberg equilibrium (HWE) filtering in large genomic studies, showing that current p-value thresholds are too strict for large samples and proposing alternative post-hoc filtering strategies.

The paper shows that burst activation of VTA dopamine neurons leads to prolonged dopamine availability in brain regions, mediated by Rho-mediated dopamine transporter internalization.