Mitchell A. Ellison

This paper reassesses Hardy-Weinberg equilibrium (HWE) filtering in large genomic studies, showing that current p-value thresholds are too strict for large samples and proposing alternative post-hoc filtering strategies.

The paper identifies a direct interaction between Cdc73 and Spt6, showing Spt6 is required for Paf1C recruitment to active genes in yeast.

The paper identifies a genetic interaction between the Hda1C histone deacetylase and the H2B ubiquitylation pathway in regulating chromatin structure during transcription elongation in yeast.

MutantHuntWGS is a pipeline for analyzing Saccharomyces cerevisiae whole-genome sequencing data, identifying causal variants and providing reproducible results through containerization.

The paper identifies the nucleosome DNA entry-exit site as critical for transcription termination in yeast by showing that mutations affecting this site lead to transcriptional readthrough.

This study investigates the role of the Paf1 complex in regulating the transcriptome of Saccharomyces cerevisiae, revealing its impact on both coding and noncoding transcripts through transcriptional and post-transcriptional mechanisms.