Xinbao Ding

This study models human MLH1 and MLH3 variants in mice, revealing MutLγ's roles in meiotic DNA repair and ovarian reserve maintenance through multiple mechanisms.

This paper develops a scalable method to generate PGC-like cells and uses it to identify epigenetic factors affecting germline development.

The paper evaluates the functional impact of missense variants in human reproductive genes using mouse models and finds that many predicted pathogenic variants do not cause detectable phenotypes.

The paper identifies two RABL2A variants causing male infertility and ciliopathies by combining in silico predictions, protein stability assays, and mouse modeling.

The paper demonstrates the production of offspring from oocytes derived from mouse spermatogonial stem cells through chromatin reorganization and identifies key factors involved in germline stem cell conversion.