NeurosciencebioRxivPreprint
Repurposed COMT Inhibitors Tolcapone and Entacapone Selectively Suppress Aggregation and Seeding of P301 Mutant TAU in Human Neuronal Models
DOI 10.64898/2026.04.20.719548
Author
University Hospital OlomoucORCID 0000-0001-5973-5990Unclaimed ORCID profile · follow to get notified of new preprints
2 papers
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Narendran Annadurai, Agáta Kubíčková, Ivo Frydrych…·Viswanath Das
This study examines how R2 and R3 fibrils differentially affect autophagic degradation of tau aggregates in Tau K18 P301S cells, showing that EGCG enhances autophagy and reduces aggregation.