Author

Lukas Schmidheini

University of ZurichORCID 0000-0001-5993-9985Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Desirée BöckiD· 3 shared Gerald SchwankiD· 3 shared Eleonora I. IoannidiiD· 2 shared Sharan JanjuhaiD· 2 shared Tanja RothgangliD· 2 shared Ahmed AllamiD· 1 shared András TálasiD· 1 shared Bas van SteenseliD· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersGenetics

Desirée BöckORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintOct 9, 2023

Predicting prime editing efficiency across diverse edit types and chromatin contexts with machine learning

Nicolas Mathis, Ahmed Allam, András Tálas…·Gerald Schwank

7 citations

machine learning (classical)variant effect prediction

𝕏 PostBluesky

GeneticsbioRxivPreprintMay 19, 2023

Prime editing of the beta-1 adrenoceptor in the brain reprograms mouse behavior

Desirée Böck, Lisa Tidecks, Maria Wilhelm…·Gerald Schwank

This study uses prime editing in mice brains to introduce a mutation in the Adrb1 gene, leading to increased activity and exploratory behavior.

4 citations

mouseexperimental assay

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GeneticsbioRxivPreprintAug 17, 2021

Treatment of a metabolic liver disease by in vivo prime editing in mice

Desirée Böck, Tanja Rothgangl, Lukas Villiger…·Gerald Schwank

In vivo prime editing corrects phenylketonuria in mice by repairing the Pah gene mutation and reducing blood phenylalanine levels.

3 citations

mouseCRISPR screen

𝕏 PostBluesky