Author

Maria Wilhelm

University of ZurichORCID 0009-0002-9935-5161Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Assay:electronic health records· 2

Frequent Co-Authors

Tommaso PatriarchiiD· 3 shared Desirée BöckiD· 2 shared Gerald SchwankiD· 2 shared Jonas MumenthaleriD· 2 shared A MarinescuiD· 1 shared Alessio CremonesiiD· 1 shared Anahita RassiiD· 1 shared Daniel Fabio Carpanese· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersNeuroscience

Tommaso PatriarchiORCID

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4 papers

Recent·Most cited

Hippocampal neuronal and astrocytic responses to noradrenaline and natural arousal

Sian N. Duss, Maria Wilhelm, A Marinescu, Runzhong Zhang, Fritjof Helmchen, Johannes Bohacek, Peter Rupprecht

This study compares natural arousal and direct locus coeruleus activation in mouse hippocampal CA1, revealing distinct cellular response patterns in astrocytes and neurons.

bioRxiv · Apr 8, 2026 · PreprintNeuroscience

Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model for Parkinson's disease

Desirée Böck, Maria Wilhelm, Jonas Mumenthaler, Daniel Fabio Carpanese, Péter István Kulcsár, Simon d‘Aquin, Alessio Cremonesi, Anahita Rassi, Johannes Häberle, Tommaso Patriarchi, Gerald Schwank

This study uses base editing to downregulate PTBP1 in neurons of a PD mouse model, rescuing motor symptoms without affecting astrocytes.

eLife · Dec 13, 2024Peer-reviewedNeuroscience

Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner

Masaya Harada, Laia Serratosa Capdevila, Maria Wilhelm, Denis Burdakov, Tommaso Patriarchi

This study shows that dopamine release in the lateral hypothalamus (LH) increases orexin neuron activity through dopamine D2 receptors, revealing a new mechanism linking dopamine and reward expectation.

eLife · Oct 18, 2023Peer-reviewedNeuroscience

Prime editing of the beta-1 adrenoceptor in the brain reprograms mouse behavior

Desirée Böck, Lisa Tidecks, Maria Wilhelm, Yanik Weber, Eleonora I. Ioannidi, Jonas Mumenthaler, Tanja Rothgangl, Lukas Schmidheini, Sharan Janjuha, Tommaso Patriarchi, Gerald Schwank

This study uses prime editing in mice brains to introduce a mutation in the Adrb1 gene, leading to increased activity and exploratory behavior.

bioRxiv · May 19, 2023 · PreprintGenetics