Qiuchen Meng

scRecover imputes dropout zeros in scRNA-seq data while preserving true zeros, improving downstream analysis through accurate zero discrimination.

This study benchmarks 12 multi-omics integration methods on scRNA-seq and scATAC-seq data across three tasks, identifying method-specific strengths and providing selection guidelines.

scDecouple separates true cellular response from gRNA infection bias in scCRISPR-seq data, improving gene perturbation analysis in heterogeneous samples.

The paper constructs a generic chromatin accessibility reference (cPeaks) from bulk ATAC-seq data to improve scATAC-seq analysis and cell type identification.

The paper introduces hECA, a cell-centric human Ensemble Cell Atlas, which integrates scRNA-seq data from multiple studies to enable targeted data retrieval, multi-view presentations, and customizable reference creation for cell type annotations.