Wei Li

This paper introduces an alternative spherical coordinate system for protein structure description using Caenopore-5, demonstrating its potential to enhance geometric fidelity in structure prediction.

This paper computationally designs semaglutide analogues to enhance GLP-1R activation using structural biophysics, resulting in 564 analogues with improved binding affinity.

This paper develops a scalable computational workflow to generate antigen-antibody binding affinity landscapes, focusing on Trastuzumab, to improve ADC design and AI-based drug discovery.