Guido Barzaghi

The paper quantifies enhancer activation frequency in response to TF perturbations and identifies H3K27Ac as a chromatin mark required for enhancer activation.

FootprintCharter detects and quantifies footprints in single molecule footprinting data without prior assumptions on genomic locations.

COBIND identifies TF co-binding patterns using NMF on TFBS data, revealing both known and novel co-binding configurations across species.

The paper uses single molecule multi-omics to show DNA methylation can block transcription factor binding at cell-type-specific enhancers, but not all enhancers.

The paper uses single molecule footprinting to study transcription factor co-occupancy and cooperativity in mouse cis-regulatory elements, finding that high DNA co-occupancy can occur without direct physical interaction.