Emmet A. Francis

This paper develops a computational model to study how store-operated calcium entry (SOCE) affects force generation and fatigue during exercise by simulating calcium and phosphate dynamics in skeletal muscle.

The paper develops a finite-element framework to simulate mechanochemical feedback in cell shape and mechanics, revealing new insights into cell migration, neutrophil protrusion, and dendritic spine remodeling.

This paper develops a mechanochemical model to predict nuclear deformation and lamina remodeling in response to substrate nanotopography and validates predictions through experiments.

This study shows nanoscale membrane curvature and nuclear deformation regulate mechanotransduction by modulating YAP/TAZ nuclear localization through biophysical modeling and experiments.

The paper introduces SMART, a software tool for simulating cell signaling networks in realistic geometries, demonstrating its application to various biological systems.

This study develops a computational model showing mechanotransduction modulates the mammalian circadian clock by affecting YAP/TAZ and MRTF nuclear translocation, with implications for disease states.