O-GlcNAcylation-Ubiquitin Crosstalk of METTL1 Drives m7G Epitranscriptomic Collapse and Lipid Metabolic Reprogramming in Diabetic Cardiomyopathy
Xin Gu, Haoyu Meng, Jiabao Liu, Yan Liang, Baihong Li, Fen Wang, Qian S. Liu, Zhixuan Zhang, Jialong Liang, Xiaodong Zhang, Jialong Sun, Jianwei Li, Feng Liu, Xiao Wang, Guangyi Huang, , Yingqiang Du
This study identifies METTL1 O-GlcNAcylation and ubiquitination as key regulators of m7G modification and lipid metabolism in diabetic cardiomyopathy, with a drug targeting this pathway showing therapeutic potential.
bioRxiv · Jul 7, 2025 · PreprintPathology