Margo P. Cain

This study shows that alveolar type 1 cells play an intermediary role in lung epithelial repair during Sendai virus infection by persisting in AT2-cell-depleted areas and interacting with immune cells.

The paper introduces a quantitative method to construct ligand-receptor interactomes from scRNA-seq data and applies it to mouse lungs infected with Sendai virus.

The paper shows that Vegfa from alveolar type 1 cells specifies a distinct endothelial population in the mouse lung, marked by Car4 and involved in alveologenesis.