Bin Zhou

This study shows that cardiomyocytes can transition to a mesenchymal-like fate during myocardial fibrosis, regulated by HGS and ALDH1A2, contributing to fibrosis and calcification.

This study identifies desert hedgehog (DHH) as a resilience factor that prevents atherosclerosis by inhibiting PAI-1 signaling and endothelial mesenchymal transition.

This paper introduces two new Cre systems, roxCre and loxCre, for improved conditional gene targeting and lineage tracing in vivo.

This study identifies abnormal ventricular wall patterning as a driver of MYBPC3-related hypertrophic cardiomyopathy through disrupted cardiomyocyte proliferation and Prdm16 regulation.

The paper maps the spatiotemporal distribution and lineage relationships of NFATc1+/PDGFR-alpha+ cells in dental and periodontal mesenchyme using genetic tools and advanced imaging.

The paper introduces an interleaved intersectional reporter (IIR) strategy to improve genetic lineage tracing specificity by combining inducible CreER with constitutively active Dre, enabling precise tracking and functional analysis of cardiac fibroblasts.

The paper identifies an intermediate basal cell population (Basal-B) in the prostate that shows lineage plasticity and contributes to both homeostasis and cancer initiation.

This study identifies NFATc1 as a key regulator that negatively controls articular chondrocyte differentiation in mouse knee development.

This paper identifies a novel metaphyseal skeletal stem cell (mpSSC) population derived from hypertrophic chondrocytes that supports trabecular bone formation.

The paper identifies a specialized fetal bone marrow niche regulated by arterial endothelial cells and Wnt2 signaling that supports hematopoietic stem and progenitor cell expansion.

The paper shows that Vegfa from alveolar type 1 cells specifies a distinct endothelial population in the mouse lung, marked by Car4 and involved in alveologenesis.

This study shows that reduced gene dosage in multiple genes causes multisystem disorders in DM1 by creating mouse models with multigene mutations.

The paper uses single-cell RNA-seq to study cardiac outflow tract development in mice, identifying new cell lineages and transitions, including myocardial to VSMC trans-differentiation.

This study shows that regulatory T-cells are essential for neonatal heart regeneration, as their depletion impairs cardiac repair and increases fibrosis.