Author

Tsung‐Han Chou

Cold Spring Harbor LaboratoryORCID 0000-0001-6154-6283Unclaimed ORCID profile · follow to get notified of new preprints

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Neuroscience· 1

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Approach:experimental assay· 1

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Hiro FurukawaiD· 1 shared Max EpsteiniD· 1 shared Ruben Steigerwald· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperNeuroscience

Hiro FurukawaORCID

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1 paper

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NeurosciencebioRxivPreprintNov 6, 2025

On the mechanism of calcium permeability and magnesium block in NMDA receptors - a central molecular paradigm in neuroplasticity

Ruben Steigerwald, Max Epstein, Tsung‐Han Chou, Hiro Furukawa

This study elucidates the molecular mechanism of Ca2+ permeability and Mg2+ block in NMDA receptors, showing how Ca2+ partially dehydrates to pass through the selectivity filter while Mg2+ remains hydrated and blocks the channel.

DOI 10.1101/2025.11.06.686637

experimental assay

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