Hiro Furukawa

This study elucidates the molecular mechanism of Ca2+ permeability and Mg2+ block in NMDA receptors, showing how Ca2+ partially dehydrates to pass through the selectivity filter while Mg2+ remains hydrated and blocks the channel.

The paper identifies a complex formed by non-catalytic and catalytic TPSs and a TPP, showing their interaction regulates maize development.

This study shows a patient-derived monoclonal antibody rapidly inhibits N-methyl-D-aspartate receptors directly, suggesting potential therapeutic strategies using antigen-binding fragments.

The paper investigates the molecular mechanisms of behavioral time scale plasticity (BTSP) in CA1 synapses, finding that delayed, dendritic, and stochastic CaMKII activation (DDSC) is essential for BTSP.

The paper presents the cryo-EM structure of a pannexin 1 channel, revealing an extracellular gating mechanism and identifying key residues involved in ion selectivity and channel inhibition.