Ryota L. Matsuoka

The paper identifies the Ccbe1-Adamts-Vegfc axis as critical for cerebrovascular regionalization in zebrafish by regulating fenestrated vascular patterning.

The paper identifies a multipotent vascular niche in zebrafish that generates BBB and fenestrated endothelial cells, revealing Flt4's role in their segregation through signaling with Vegfr2.

The paper identifies a core angiogenic mechanism involving Vegfc/d and Vegfa that drives region-specific development of fenestrated capillaries in the brain.

This paper introduces a triple dgRNP CRISPR system for efficient biallelic gene disruption in zebrafish, enabling rapid cardiovascular phenotyping in F0 embryos.

This study shows that mesodermal cells can differentiate into insulin-producing β-cells without endothelial specification, revealing a new pathway for β-cell regeneration in zebrafish.