Author

Luke D. Buck

Cleveland ClinicORCID 0000-0002-0484-3860Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:zebrafish· 3 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Ryota L. MatsuokaiD· 3 shared Rachael E. QuickiD· 2 shared Sweta ParabiD· 2 shared Alyssa G. Storm· 1 shared Amanda E. Lam· 1 shared Angelene A. Getz· 1 shared Benoît VanhollebekeiD· 1 shared Ella Kazazic· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersDevelopmental Biology

Ryota L. MatsuokaORCID

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3 papers

Recent·Most cited

The lymphangiogenic Ccbe1-Adamts-Vegfc axis shapes cerebrovascular regionalization via selective patterning of fenestrated vascular beds

Luke D. Buck, Vani Thakur, Alyssa G. Storm, Fatma Z. Bozdag, Nathanael J. Lee, Jun Xiong Leong, Ella Kazazic, Amanda E. Lam, Angelene A. Getz, Ryota L. Matsuoka

The paper identifies the Ccbe1-Adamts-Vegfc axis as critical for cerebrovascular regionalization in zebrafish by regulating fenestrated vascular patterning.

bioRxiv · Oct 16, 2026 · PreprintDevelopmental Biology

Local angiogenic interplay of Vegfc/d and Vegfa drives brain region-specific development of fenestrated capillaries

Sweta Parab, Olivia A. Card, Qiyu Chen, Michelle America, Luke D. Buck, Rachael E. Quick, William F Horrigan, Gil Levkowitz, Benoît Vanhollebeke, Ryota L. Matsuoka

The paper identifies a core angiogenic mechanism involving Vegfc/d and Vegfa that drives region-specific development of fenestrated capillaries in the brain.

eLife · May 16, 2023Peer-reviewedDevelopmental Biology

Highly efficient synthetic CRISPR RNA/Cas9-based mutagenesis for rapid cardiovascular phenotypic screening in F0 zebrafish

Rachael E. Quick, Luke D. Buck, Sweta Parab, Zane R. Tolbert, Ryota L. Matsuoka

This paper introduces a triple dgRNP CRISPR system for efficient biallelic gene disruption in zebrafish, enabling rapid cardiovascular phenotyping in F0 embryos.

Frontiers in Cell and Developmental Biology · Oct 22, 2021Peer-reviewedDevelopmental Biology