Cell BiologyThe Journal of Cell BiologyPeer-reviewed
Origin of Chromosome 12 Trisomy Surge in Human Induced Pluripotent Stem Cells (iPSCs)
Maria Narożna, Megan C. Latham, Gary J. Gorbsky
This paper challenges the conventional view of trisomy 12 origin in iPSCs by showing it arises de novo in diploid cells through anaphase bridging and micronuclei formation, leading to rapid dominance of trisomic cells.
5 citations