Author

Catherine E. Thomas

University of PittsburghORCID 0000-0003-0645-4209Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

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John J. AlvaradoiD· 1 shared Thomas E. SmithgalliD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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2 top collaborators · 1 mutual co-author link

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1 shared paperMicrobiology

John J. AlvaradoORCID

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1 paper

Recent·Most cited

MicrobiologybioRxivPreprintAug 11, 2026

HIV-1 Nef Homodimerization as a Structural Mechanism for Kinase Activation and Small Molecule Inhibitor Action

Catherine E. Thomas, John J. Alvarado, Thomas E. Smithgall

This study shows that HIV-1 Nef homodimerization is critical for kinase activation and that disrupting this interface with small molecules inhibits viral replication and restores immune recognition.

DOI 10.64898/2026.08.10.744017

humanprotein structure

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