Kristin M. Boulier

This study evaluates the reliability of coronary artery disease polygenic risk scores across diverse populations, finding poor individual agreement despite equivalent population-level performance.

The paper introduces context-aware prediction intervals for polygenic scores to improve calibration across diverse populations and traits.

This study develops multi-ancestry polygenic risk scores for venous thromboembolism using diverse GWAS data and shows improved predictive performance across European- and African-ancestry populations.

This paper evaluates a European-derived polygenic score for tobacco use disorder in a diverse biobank, finding inconsistent performance across ancestries and associations with systemic health risks.

The paper evaluates polygenic score accuracy across genetic ancestry continua in diverse populations, finding significant variation in performance linked to genetic distance from training data.

The paper explores the relationship between genomic ancestry and health outcomes using a biobank linked to electronic health records, finding disease stratification across ancestry clusters.