Author

Ziqi Xu

University of California, Los AngelesPrimary ORCID profile (0000-0001-5272-8456 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Ziqi XuiD2 papers · South China Agricultural University

Biology Disciplines

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Genetic & Genomic Medicine· 2 Genetics· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:benchmarking· 2 Assay:whole-genome sequencing· 2 Research Focus:eQTL / molecular QTL mapping· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Bogdan PaşaniuciD· 3 shared Kangcheng HouiD· 3 shared Yi DingiD· 3 shared Kristin M. BoulieriD· 2 shared Aditya PimplaskariD· 1 shared Ani W ManichaikuliD· 1 shared Arbel HarpakiD· 1 shared Arjun BhattacharyaiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Bogdan PaşaniucORCID

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4 papers

Recent·Most cited

Estimating the cis-heritability of gene expression using single cell expression profiles controls false positive rate of eGene detection

Ziqi Xu, Arya R Massarat, Laurie Rumker, Melissa Gymrek, Soumya Raychaudhuri, Wei Zhou, Tiffany Amariuta

The paper introduces scGeneHE, a method to estimate cis-heritability from scRNA-seq data, reducing false positives in eGene detection.

bioRxiv · Feb 24, 2025 · PreprintGenetics

Calibrated prediction intervals for polygenic scores across diverse contexts

Kangcheng Hou, Ziqi Xu, Yi Ding, Ravi Mandla, Zhuozheng Shi, Kristin M. Boulier, Arbel Harpak, Bogdan Paşaniuc

The paper introduces context-aware prediction intervals for polygenic scores to improve calibration across diverse populations and traits.

Nature Genetics · Jun 17, 2024Peer-reviewedGenetic & Genomic Medicine

Polygenic scoring accuracy varies across the genetic ancestry continuum in all human populations

Yi Ding, Kangcheng Hou, Ziqi Xu, Aditya Pimplaskar, Ella Petter, Kristin M. Boulier, Florian Privé, Bjarni Jóhann Vilhjálmsson, Loes M. Olde Loohuis, Bogdan Paşaniuc

The paper evaluates polygenic score accuracy across genetic ancestry continua in diverse populations, finding significant variation in performance linked to genetic distance from training data.

bioRxiv · Sep 28, 2022 · PreprintGenetics

Causal effects on complex traits are similar across segments of different continental ancestries within admixed individuals

Kangcheng Hou, Yi Ding, Ziqi Xu, Yue Wu, Arjun Bhattacharya, Rachel Mester, Gillian M. Belbin, David V. Conti, Burcu F. Darst, Myriam Fornage, Christopher R. Gignoux, Xiuqing Guo, Christopher A Haiman, Eimear E. Kenny, Michelle Kim, , Bogdan Paşaniuc

The paper quantifies similarity in causal effects across local ancestries in admixed individuals and finds high genetic correlation (radmix=0.95) within individuals.

medRxiv · Aug 16, 2022 · PreprintGenetic & Genomic Medicine