Anand Venkataraman

ASCOT identifies key regulators of neuronal subtype-specific splicing by analyzing public RNA-Seq data and demonstrating the role of PTBP1, MSI1, and PCBP2 in rod photoreceptor splicing.

The paper shows that Lhx2, with its coactivator Ldb1 and corepressor Rnf12, regulates the balance between neurogenesis and gliogenesis in the retina by controlling cell cycle exit, Notch signaling, and expression of neurogenic factors.

The paper develops a collection of 1406 validated monoclonal antibodies against human transcription factors and identifies factors contributing to their successful generation.