Jimmy de Melo

The paper shows that Lhx2, with its coactivator Ldb1 and corepressor Rnf12, regulates the balance between neurogenesis and gliogenesis in the retina by controlling cell cycle exit, Notch signaling, and expression of neurogenic factors.

The paper develops a collection of 1406 validated monoclonal antibodies against human transcription factors and identifies factors contributing to their successful generation.