BiophysicsbioRxivPreprint
PolyA/polyQ-mediated conformational rewiring regulates DNA engagement and drives aggregation in the neuronal transcription factor Ascl1
Shrutarshi Mitra, Sarah F. Ruidiaz, Asdis Laufeyjardottir…·Pétur O. Heidarsson
This study shows that the polyA/polyQ tract in Ascl1 regulates DNA engagement and aggregation through conformational changes, affecting solubility and cellular abundance.
DOI 10.64898/2026.05.11.724289