Author

Sarah F. Ruidiaz

University of CopenhagenORCID 0000-0002-7434-9737Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Andrea Guala· 1 shared Asdis Laufeyjardottir· 1 shared Eleni KafkiaiD· 1 shared Gertrud M. HjortøiD· 1 shared Haiyue LiuiD· 1 shared Jan Jakub ŻylicziD· 1 shared Kateryna NitsenkoiD· 1 shared Kenneth S. ZaretiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Andrea Guala

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2 papers

Recent·Most cited

PolyA/polyQ-mediated conformational rewiring regulates DNA engagement and drives aggregation in the neuronal transcription factor Ascl1

Shrutarshi Mitra, Sarah F. Ruidiaz, Asdis Laufeyjardottir, Vasileios Voutsinos, Kateryna Nitsenko, Andrea Guala, Kenneth S. Zaret, Rasmus Hartmann‐Petersen, Pétur O. Heidarsson

This study shows that the polyA/polyQ tract in Ascl1 regulates DNA engagement and aggregation through conformational changes, affecting solubility and cellular abundance.

bioRxiv · Sep 25, 2026 · PreprintBiophysics

SCAF1 driven polyadenylation site usage regulates mRNA isoform expression and neuronal differentiation

Smaragda Kompocholi, Nikolaos Stamidis, Haiyue Liu, Gertrud M. Hjortø, Eleni Kafkia, Sarah F. Ruidiaz, Thomas C. R. Miller, Jan Jakub Żylicz, Lea H. Gregersen

This study shows that SCAF1 regulates polyadenylation site usage, affecting mRNA isoform expression and neuronal differentiation in mouse embryonic stem cells.

bioRxiv · Dec 10, 2025 · PreprintMolecular Biology