Kenneth S. Zaret

PolyA/polyQ-mediated conformational rewiring regulates DNA engagement and drives aggregation in the neuronal transcription factor Ascl1

This study shows that the polyA/polyQ tract in Ascl1 regulates DNA engagement and aggregation through conformational changes, affecting solubility and cellular abundance.

ERH elicits cell lineage restriction in mammalian preimplantation development and differentiation from pluripotency via H3K9me3-heterochromatin

This study shows ERH maintains H3K9me3 heterochromatin in mammalian cells, restricting lineage potential and repressing pluripotency genes during development and reprogramming.

H3K9me3 as a gatekeeper of lineage-specific enhancers in embryonic progenitor cells

The paper shows H3K9me3 represses lineage-specific enhancers in progenitor cells, restricting transcription factor access to prevent inappropriate activation during development.

Lineage memory shapes viral resistance barriers in human skin

The paper shows that viral resistance in human skin cells is inherited through cellular lineages and preserved across generations.

Distinct H3K9me3 heterochromatin maintenance dynamics govern different gene programs and repeats in pluripotent cells

The paper investigates H3K9me3 heterochromatin dynamics in pluripotent cells, revealing distinct decay rates and mechanisms that maintain pluripotency.

Distinct chromatin scanning modes lead to targeting of compacted chromatin by pioneer factors FOXA1 and SOX2

The paper shows that pioneer factors FOXA1 and SOX2 use distinct chromatin scanning dynamics to target compacted chromatin, while non-pioneer HNF4A targets open chromatin regions.

Characterizing the Emergence of Liver and Gallbladder from the Embryonic Endoderm through Single-Cell RNA-Seq

The paper uses single-cell RNA-seq to study liver and gallbladder development from the embryonic endoderm, identifying key transcription factors and gene expression changes during differentiation.

Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPS cells

This study compares OSKM reprogramming factor binding in human and mouse fibroblasts, finding conserved mechanisms and species-specific differences in target sites and regulatory networks.