Author

Xiaoheng Cheng

University of ChicagoORCID 0000-0003-4967-8907Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:human· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Matthias SteinrückeniD· 2 shared Adam S. ButterworthiD· 1 shared Adriana MendeziD· 1 shared Aitzkoa Lopez de Lapuente PortillaiD· 1 shared Alison M. DevaultiD· 1 shared Allison E. Ashley‐KochiD· 1 shared Andrew LeeiD· 1 shared Angelika Hammerer‐LercheriD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenetics

Matthias SteinrückenORCID

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3 papers

Recent·Most cited

Genetic & Genomic MedicineNaturePeer-reviewedSep 30, 2026

Human genetics implicates a BACH2-NRF2 axis in fetal hemoglobin activation

C. Guo, Uma P. Arora, Xiaoheng Cheng…·Vijay G. Sankaran

This study identifies a BACH2-NRF2 axis regulating fetal hemoglobin activation through genetic and functional analyses in a large multi-ancestry cohort.

DOI 10.1038/s41586-026-11113-2

humanGWAS summary statistics

𝕏 PostBluesky

GeneticsG3 Genes Genomes GeneticsPeer-reviewedJun 6, 2025

diplo-locus: A lightweight toolkit for inference and simulation of time-series genetic data under general diploid selection

Xiaoheng Cheng, Matthias Steinrücken

The paper introduces diplo-locus, a Python toolkit for simulating and inferring parameters from time-series genetic data under diploid selection models.

4 citations

whole-genome sequencingstatistical model

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GenomicsbioRxivPreprintApr 6, 2023

Reply to Barton et al: signatures of natural selection during the Black Death

Tauras P. Vilgalys, Jennifer Klunk, Christian E. Demeure…·Luis Bruno Barreiro

The paper addresses statistical concerns about detecting natural selection during the Black Death using ancient genomic data, reaffirming findings related to immune loci and the ERAP2 variant.

3 citations

humanwhole-genome sequencing

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