Jérémy Signoret-Genest

This study investigates how different frequencies and amplitudes of DBS in the MLR affect behavior in rats, finding that high-frequency stimulation induces hyperlocomotion and defensive behaviors, while low-frequency stimulation causes immobility.

The paper develops a cell-type specific viral vector mouse model to induce synucleinopathy in individual circuit elements and characterizes its pathological features.

The paper defines cardio-behavioural microstates linked to threat and demonstrates freezing as part of an integrated microstate mediated by midbrain circuits.