Philip Tovote

Deep brain stimulation of the mesencephalic locomotor centre induces stimulation-dependent behavioural states beyond locomotion

This study investigates how different frequencies and amplitudes of DBS in the MLR affect behavior in rats, finding that high-frequency stimulation induces hyperlocomotion and defensive behaviors, while low-frequency stimulation causes immobility.

A viral vector model for circuit-specific synucleinopathy

The paper develops a cell-type specific viral vector mouse model to induce synucleinopathy in individual circuit elements and characterizes its pathological features.

Integrated cardio-behavioural defensive states

The paper defines cardio-behavioural microstates linked to threat and demonstrates freezing as part of an integrated microstate mediated by midbrain circuits.

Sylites: Multipurpose markers for the visualization of inhibitory synapses

The paper introduces Sylites, fluorogenic probes for visualizing inhibitory synapses with high contrast and selectivity, enabling precise nanoscopic measurements and 3D distribution analysis in brain tissue.