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A.C. Robinson

Johns Hopkins UniversityORCID 0000-0001-6410-7147Unclaimed ORCID profile · follow to get notified of new preprints

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Approach:experimental assay· 1

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Bertrand García‐Moreno E.iD· 1 shared Christos M. KougentakisiD· 1 shared Miranda N. HurstiD· 1 shared

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BiophysicsbioRxivPreprintDec 2, 2025

The pKa values of buried ionizable amino acids can be determined by the thermodynamic stability of the protein

Miranda N. Hurst, Christos M. Kougentakis, A.C. Robinson, Bertrand García‐Moreno E.

This study shows that the pKa values of buried ionizable amino acids in proteins correlate with the thermodynamic stability of the protein, indicating that they reflect conformational transition energetics rather than local electrostatic properties.

DOI 10.64898/2025.11.30.690581

experimental assay

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