Christos M. Kougentakis

This study shows that the pKa values of buried ionizable amino acids in proteins correlate with the thermodynamic stability of the protein, indicating that they reflect conformational transition energetics rather than local electrostatic properties.

This paper introduces cataLYTACs, a new therapeutic modality that efficiently and durably degrades circulating proteins like IgE in vitro and in vivo, outperforming traditional inhibitors.

The paper develops a fluorescent probe to monitor lysosomal catabolism of internalized proteins and applies it to assess therapeutic LYTAC agents.