Kui Ming Chan

This paper identifies 4-C-3 as an antitumor metabolite derived from cholesterol by gut microbiota, showing its efficacy in CRC models through dual inhibition of EGFR and KRAS.

The paper introduces AMAPEX, a method to label proximal proteins of post-translationally modified proteins using antibody-mediated protein A-APEX2 labeling, and validates it with histone modification profiling.