Hui Shi

This study identifies CD4+ tissue-resident memory Th17 (TRM17) cells as the main source of IL-17A in SpA synovium, showing their role in disease pathology and potential as therapeutic targets.

This paper identifies 4-C-3 as an antitumor metabolite derived from cholesterol by gut microbiota, showing its efficacy in CRC models through dual inhibition of EGFR and KRAS.

The paper identifies trained immunity in AS monocytes and shows their enhanced response to T-cell activation, contributing to Th17 responses and disease pathology.

The paper investigates how 3D genome structure influences protein-protein interactions and shows that gene proximity in 3D space correlates with interaction likelihood.