Kathleen A. Grant

The role of serotonin in the orbitofrontal cortex in alcohol consumption

This study shows that serotonin signaling in the orbitofrontal cortex influences alcohol consumption and aversion-resistant drinking in mice.

Kappa opioid receptors regulate cocaine effects on nucleus accumbens dopamine through phosphorylation of dopamine transporter at the threonine 53 site

This study shows that KOR activation leads to DAT tolerance to cocaine via phosphorylation at threonine 53, demonstrated through behavioral, electrophysiological, and genetic experiments across species.

Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner

This study shows chronic ethanol self-administration in rhesus macaques alters dopamine signaling in the caudate and putamen, with sex-specific differences in release and uptake.

Altered molecular signaling pathways in the hippocampus of rhesus monkeys following chronic alcohol use

This study identifies altered molecular pathways in the hippocampus of rhesus monkeys with chronic alcohol use, highlighting mitochondrial and synaptic changes and potential therapeutic targets.

Cross-Species Evidence for Hippocampal CACNA1C as a Therapeutic Target for Alcohol Use Disorder

The paper identifies CACNA1C as a therapeutic target for alcohol use disorder by showing increased expression in AUD and reduced ethanol-induced CPP with Nifedipine.

Chronic alcohol consumption enhances the differentiation capacity of hematopoietic stem and progenitor cells into osteoclast precursors

This study shows that chronic alcohol consumption increases the differentiation of hematopoietic stem and progenitor cells into osteoclast precursors, contributing to reduced bone density.

Synchrony between midbrain gene transcription and dopamine terminal regulation is modulated by chronic alcohol drinking

The paper examines how chronic alcohol drinking affects the relationship between gene expression and dopamine regulation in the brain, finding persistent functional changes despite no change in transcript levels.

Phenotypic and Functional Alterations in Peripheral Blood Mononuclear Cell-Derived Microglia in a Primate Model of Chronic Alcohol Consumption

This study differentiates peripheral blood mononuclear cells from non-human primates into microglia-like cells to study the effects of chronic alcohol consumption on microglial function and transcriptional profiles.

Chronic alcohol consumption alters sex-dependent BNST neuron function in rhesus macaques

This study examines sex differences in BNST neuron function in rhesus macaques following chronic alcohol exposure, finding increased excitability and synaptic excitation in both sexes.

Recurrent activity within microcircuits of macaque dorsolateral prefrontal cortex tracks cognitive flexibility

The paper examines microcircuit activity in macaque dlPFC using calcium imaging, showing that spontaneous activity is maintained by microcircuit architecture and correlates with cognitive performance.

Exploratory extracellular vesicle-bound miRNA profiling to identify candidate biomarkers of chronic alcohol drinking in non-human primates

This study identifies EV-miRNA biomarkers associated with chronic alcohol drinking in non-human primates and links them to inflammatory responses.

Cross-species epigenetic regulation of nucleus accumbens KCNN3 transcript variants by excessive ethanol drinking and dependence

This study identifies epigenetic changes in KCNN3 gene variants in alcohol-dependent monkeys and mice, linking hypermethylation to altered KCa2 channel function and potential role in alcohol use disorder.

Maternal Circulating MiRNAs That Predict Infant FASD Outcomes Influence Placental Maturation

The paper identifies maternal circulating miRNAs that predict infant FASD outcomes and show they impair placental development by inhibiting the EMT pathway in trophoblasts.