Author

William T. Heller

Oak Ridge National LaboratoryORCID 0000-0001-6456-2975Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein sequence· 1

Frequent Co-Authors

Alejandro de JanoniD· 1 shared Athanasios MantalarisiD· 1 shared Barbara R. EvansiD· 1 shared Benjamin LindneriD· 1 shared Brian H. DavisoniD· 1 shared Emal M. Alekozai· 1 shared Hugh O’NeilliD· 1 shared Jeremy Smith· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioengineering

Alejandro de JanonORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 23, 2026

Conformational Reorganization of a Processive Cellulase on Crystalline Cellulose

Sai Venkatesh Pingali, Junhong He, Loukas Petridis…·Hugh O’Neill

This study uses SANS and molecular dynamics to show that Cel7A adopts distinct conformations when bound to cellulose compared to free solution, highlighting dynamic structural changes during catalysis.

DOI 10.64898/2026.10.21.760844

experimental assay

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BioengineeringACS OmegaPeer-reviewedJan 14, 2025

Intracellular biomacromolecule delivery by stimuli responsive protein vesicles loaded by hydrophobic ion pairing

Mikaela A. Gray, Alejandro de Janon, Michelle Seeler…·Julie A. Champion

This study develops stimuli-responsive protein vesicles using hydrophobic ion pairing to deliver proteins and siRNA, showing effective delivery and functional activity in cancer cell lines and organoid models.

10 citations

humanmouse

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