Structural basis for the unexpected activity of rifamycin B against rifampicin-resistant RNA polymerase
Hamed Mosaei, Yeonoh Shin, Valery N. Kozhevnikov, Paul Gordon Waddell, Michael J. Hall, Katsuhiko S. Murakami, Nikolay Zenkin
This study reveals the structural basis for Rifamycin B's activity against rifampicin-resistant RNA polymerase, showing its unique binding mechanism and potential for drug development.
bioRxiv · Jul 14, 2026 · PreprintBiochemistry