Yeonoh Shin

Structural basis for the unexpected activity of rifamycin B against rifampicin-resistant RNA polymerase

This study reveals the structural basis for Rifamycin B's activity against rifampicin-resistant RNA polymerase, showing its unique binding mechanism and potential for drug development.

Lineage-specific amino acids define functional attributes of the protomer-protomer interfaces for the Rad51 and Dmc1 recombinases

The paper compares Rad51 and Dmc1 recombinases using structural and functional analyses to show differences in their interfacial amino acids and evolutionary trajectories.

Structural basis for Rad54- and Hed1-mediated regulation of Rad51 during the transition from mitotic to meiotic recombination

The paper identifies Rad51 interaction motifs in Rad54 and Hed1, and solves their CryoEM structures to explain their roles in regulating Rad51 activity during mitosis and meiosis.

ATP hydrolysis-driven structural transitions within the S. cerevisiae Rad51 and Dmc1 nucleoprotein filaments

The paper presents CryoEM structures of Rad51 and Dmc1 in ADP-bound states and compares them to ATP-bound filaments, revealing structural transitions linked to ATP hydrolysis and filament disassembly.

Structural basis of ribosomal RNA transcription regulation

This study reveals how DksA/ppGpp regulates rRNA transcription by altering RNAP conformation and promoter DNA binding in Escherichia coli.

Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase

The paper determines structures of bacterial RNA polymerase during reiterative transcription and reveals mechanisms of RNA slippage and product length determination at two promoters.