TRESK background potassium channel in MrgprA3+ pruriceptors regulates acute and chronic itch.
Júlia Llimós-Aubach, Alba Andrés‐Bilbé, Anna Pujol‐Coma, Irene Pallás, Josep Maria de Anta, Concepció Soler, Núria Comes, Gerard Callejo, Xavier Gasull
This study shows TRESK channels regulate non-histaminergic itch by modulating sensory neuron excitability, and enhancing TRESK function reduces acute and chronic itch in mice.
bioRxiv · Jan 25, 2024 · PreprintNeuroscience