Xavier Gasull

Adgrd1 deficiency reveals increased hippocampal vulnerability and selective behavioral alterations in mice

This study shows that Adgrd1 deficiency in mice leads to reduced nest-building, decreased exploratory behavior, and increased hippocampal vulnerability through molecular and circuit-level changes.

KCNK18 c.1107del frameshift in peripheral neuropathy links TRESK dysfunction to neuropathic pain

The paper identifies a frameshift mutation in KCNK18 causing TRESK dysfunction, linking it to neuropathic pain through haploinsufficiency and altered channel function.

TRESK background potassium channel in MrgprA3+ pruriceptors regulates acute and chronic itch.

This study shows TRESK channels regulate non-histaminergic itch by modulating sensory neuron excitability, and enhancing TRESK function reduces acute and chronic itch in mice.

RTP801 REGULATES MOTOR CORTEX SYNAPTIC TRANSMISSION AND LEARNING

This study shows that RTP801 regulates synaptic transmission and motor learning by modulating synaptic plasticity in the motor cortex.

AMPAR/TARP stoichiometry differentially modulates channel properties

The paper investigates how different stoichiometries of AMPAR-TARP complexes affect channel properties and identifies a likely functional stoichiometry in cerebellar granule cells.

TRESK background K+ channel deletion selectively uncovers enhanced mechanical and cold sensitivity

This study shows that deleting the TRESK K+ channel enhances mechanical and cold sensitivity in mice, indicating its role in regulating neuronal excitability for specific sensory functions.