Author

Ruochi Zhang

ORCID 0000-0001-6541-4050Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

Aixi Bai· 1 shared Bin Xiao· 1 shared Chenjie FengiD· 1 shared Feifei Hu· 1 shared Guiting Zhang· 1 shared Hao YeiD· 1 shared Jie WangiD· 1 shared Juexiao ZhouiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBioinformatics

Aixi Bai

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintOct 21, 2026

Reinforcement learning with evolutionary priors unlocks multi-site enzyme optimization from sparse experimental feedback

Xiaopeng Xu, Hao Ye, Ziqi Gao…·Xin Gao

AlphaVariant uses reinforcement learning with evolutionary priors to optimize enzyme variants from sparse experimental data, achieving high activity improvements in multiple rounds of optimization.

DOI 10.64898/2026.10.19.760152

protein sequencemachine learning (classical)

𝕏 PostBluesky

BioinformaticsGenomics Proteomics & BioinformaticsPeer-reviewedJun 24, 2023

AB-Gen: Antibody Library Design with Generative Pre-trained Transformer and Deep Reinforcement Learning

Xiaopeng Xu, Tiantian Xu, Juexiao Zhou…·Xin Gao

AB-Gen uses reinforcement learning and a generative pre-trained Transformer to design antibody sequences with multiple desirable properties, improving success rates over traditional methods.

32 citationstop 3%

deep learningstatistical model

𝕏 PostBluesky