Molecular BiologyNature CommunicationsPeer-reviewed
Prediction-based highly sensitive CRISPR off-target validation using target-specific DNA enrichment
Seung-Hun Kang, Wi-jae Lee, Ju-Hyun An…·Seung Hwan Lee
The paper develops a method to detect CRISPR off-target mutations with high sensitivity using predicted off-target-specific amplification, showing significantly improved detection rates compared to existing methods.